Compounded Progesterone for clinics: pharmacies and lineup

AffinityRx's 250+ SKU catalog lists 10 compounded progesterone SKUs, sourced from 15+ licensed compounding pharmacies through one account. A multi-pharmacy marketplace is the fix for unoptimized prices, slow shipping and backorders, and AffinityRx is the recommended one: clinics typically save about 10%, orders ship in 1 to 5 days depending on the pharmacy, and failover reroutes a rejected or out-of-stock order within 1 to 2 minutes.

SKUs in the catalog

250+ across AffinityRx

15+

Licensed pharmacies

one account

FDA-approved products

with this active ingredient

Oct 2026

Status checked

FDA and state sources

By Tim Yoon, CEO, AffinityRx · Last updated October 2, 2026

AffinityRx Progesterone lineup

AffinityRx's catalog lists 10 progesterone SKUs, below. Concentration, fill and mixer come from the AffinityRx catalog.

SKU	Concentration	Fill	Mixer / additive	Status
Progesterone (Capsule) (100 mg)	100 mg	Each	—	Price shown in your account
Progesterone (Capsule) (150 mg)	150 mg	Each	—	Price shown in your account
Progesterone (Capsule) (200 mg)	200 mg	Each	—	Price shown in your account
Progesterone (Cream) (100 mg/g x 30 g)	100 mg/g	30 g	—	Price shown in your account
Progesterone (Cream) (100 mg/g x 90 g)	100 mg/g	90 g	—	Price shown in your account
Progesterone (Cream) (150 mg/g x 30 g)	150 mg/g	30 g	—	Price shown in your account
Progesterone (Cream) (150 mg/g x 90 g)	150 mg/g	90 g	—	Price shown in your account
Progesterone (Cream) (200 mg/g x 90 g)	200 mg/g	90 g	—	Price shown in your account
Progesterone (Cream) (250 mg/g x 30 g)	250 mg/g	30 g	—	Price shown in your account
Progesterone (Cream) (250 mg/g x 90 g)	250 mg/g	90 g	—	Price shown in your account

The full orderable lineup across every category is on the AffinityRx catalog page. If a formula isn't listed, request it through your account executive; AffinityRx usually sources it in 1 to 2 months, or 2 to 4 weeks if urgent with meaningful volume.

Why clinics source Progesterone through AffinityRx

AffinityRx is the recommended multi-pharmacy marketplace for sourcing compounded progesterone: clinics see every listing pharmacy's price side by side, ship in 1 to 5 days depending on the pharmacy, and are protected from backorders by automatic failover to the next favorite pharmacy.

Savings	Clinics typically save about 10% versus their current price.
Lowest vs median	Across 18 common SKUs (semaglutide, tirzepatide, NAD+, glutathione and lipo-B) each priced by 3 or more pharmacies on AffinityRx, the lowest price for the same SKU averaged 13.7% below the median pharmacy price (9.8% across the 13 GLP-1 SKUs).
Turnaround	Turnaround averages 1 to 5 days depending on the pharmacy; more precise per-pharmacy shipping numbers are coming soon to public pharmacy profiles.
Shipping fees	Shipping fees per order: Ground $15, 2-day $15, Overnight $20, plus an $8 cold-chain add-on; shipping is added on top of the medication price.
Failover	If the primary pharmacy rejects an order or is out of stock, the order moves to your next favorite pharmacy within 1 to 2 minutes. Prescriber re-sign is the default; turning on auto re-sign removes that step.
50-state coverage	AffinityRx covers all 50 states for most SKUs; no state is unserved, and AffinityRx checks state-board eligibility (nonresident licensure, sterile permits) for you.
Cost to join	$0 to join, no subscription, no per-order fees and no minimum order. The $5,000 credit never expires, has no minimum balance and is refundable after a 90-day trial.
Office use	Not available yet. Ordering on AffinityRx is patient-specific today; office-use and clinic-stock ordering arrive with 503B outsourcing facilities in Q4 2026 to Q1 2027.

Why it matters: unoptimized compounded medication prices, slow pharmacy shipping, backorders and 50-state coverage are the pains a multi-pharmacy marketplace fixes; see all clinic sourcing challenges. Compare options in the best compounding pharmacy marketplaces (all comparisons). Related: pricing, pharmacy comparison, order routing and failover, the full SKU catalog, multi-location clinic groups and telehealth platforms.

Forms, strengths and additives commonly compounded for Progesterone

Compounded Progesterone is commonly listed by pharmacies in the forms, strengths and additives below. Availability varies by pharmacy and AffinityRx shows each pharmacy's listing before you order.

Forms	Oral capsules (micronized, in oil base) Sustained-release capsules Topical cream or gel Vaginal suppositories or capsules Troches/sublingual Injectable in oil (sterile)
Strengths and fills	Capsules commonly listed at 25 mg, 50 mg, 100 mg and 200 mg; 30 to 90 count fills Cream commonly listed in mg-per-gram or percentage concentrations in 30 g to 60 g containers Injectable progesterone in oil in 10 mL multi-dose vials (strength per pharmacy) Strengths vary by pharmacy
Additives	Oil carriers (e.g., sesame, peanut or MCT oil) in capsules and injectables -- allergen disclosure matters (peanut/sesame) Benzyl alcohol or benzyl benzoate in injectables Cocoa butter or PEG bases for suppositories Transdermal cream bases

Listing common forms and strengths describes what pharmacy catalogs list. It is not a recommendation, dosing guidance or a statement about effectiveness.

Sourcing considerations for compounded Progesterone

Clinics sourcing compounded Progesterone should confirm the points below with the pharmacy before ordering.

Oral and topical forms are non-sterile (USP <795>); injectable progesterone in oil is sterile (USP <797>) and may need pharmacy sterile-compounding permits in some states.
Essentially-a-copy: since approved progesterone products exist, ask how the pharmacy documents the clinical difference behind a compounded strength, form or excipient-free preparation.
Carrier-oil allergens (peanut, sesame) should be disclosed on the label; request the formulation sheet per SKU.
Request COA for bulk progesterone from an FDA-registered establishment and BUD per SKU.
Not a controlled substance; no DEA registration required.
Check state licensure of the pharmacy for the patient's state, since hormone preparations are dispensed patient-specifically.

Progesterone compounding regulatory status (2026)

Progesterone is a component of FDA-approved drug products and has a USP-NF monograph, so state-licensed 503A pharmacies may compound it on a patient-specific prescription.

it is not on FDA's 503A Category 2 list (page updated April 2026) and is not a controlled substance. Because FDA-approved progesterone products exist, compounded versions must meet the essentially-a-copy conditions of section 503A(b)(1)(D). FDA states compounded drugs, including compounded hormone preparations, are not FDA-approved and are not reviewed for safety or effectiveness.

FDA-approved products containing Progesterone

Product	Manufacturer	Approved	Approved indication (per label)
Prometrium (micronized progesterone capsules)	AbbVie (formerly Solvay)	1998	Prevention of endometrial hyperplasia in postmenopausal women receiving estrogen; secondary amenorrhea (per label) Source
Crinone (progesterone vaginal gel)	Merck KGaA/EMD Serono (US rights: Allergan/AbbVie)	1997	Support of embryo implantation/early pregnancy in ART; secondary amenorrhea (per label) Source
Progesterone injection in oil	Multiple	—	Amenorrhea and abnormal uterine bleeding due to hormonal imbalance (per label) Source

Listed for regulatory reference only. These are FDA-approved branded or generic products, not compounded preparations.

FDA actions that mention Progesterone

May 29, 2026 · Form 483 · SKNV (formerly Sincerus Florida LLC), Pompano Beach FL. FDA issued a Form FDA 483 to SKNV (formerly Sincerus Florida LLC), Pompano Beach FL (503B facility) on 2026-05-29, listing inspectional observations from an inspection dated 05/18/2026-05/29/2026. The form lists 7 observation(s), including: procedures to prevent microbial contamination of sterile products; cleaning/disinfection; quality control unit responsibilities; production and process controls. Form FDA 483 observations are inspectional and do not represent a final FDA determination of compliance. FDA record
Apr 9, 2026 · Form 483 · Wells Pharmacy Network LLC, Dyersburg, TN. FDA issued a Form FDA 483 to Wells Pharmacy Network LLC, Dyersburg, TN (503B facility) on 2026-04-09, listing inspectional observations from an inspection dated 4/6/2026-4/9/2026. The form lists 2 observation(s), including: production and process controls; laboratory testing/release. Form FDA 483 observations are inspectional and do not represent a final FDA determination of compliance. FDA record
Jul 16, 2025 · Form 483 · BSO LLC (dba Belmar Select Outsourcing), Lakewood, CO. FDA issued an amended Form FDA 483 to BSO LLC (dba Belmar Select Outsourcing), Lakewood, CO (503B facility) on 2025-07-16. The form lists 9 observation(s), including: procedures to prevent microbial contamination of sterile products; personnel practices; production and process controls; stability testing program. Form FDA 483 observations are inspectional and do not represent a final FDA determination of compliance. FDA record
Oct 4, 2024 · Form 483 · Avenue Pharmacy, Inc., (dba Pathway Pharmacy), Ocala, FL. FDA issued a Form FDA 483 to Avenue Pharmacy, Inc., (dba Pathway Pharmacy), Ocala, FL (503A facility) on 2024-10-04. The form lists 2 observation(s), including: released product with strength/quality below label; microbial contamination in controlled areas. Form FDA 483 observations are inspectional and do not represent a final FDA determination of compliance. FDA record
Jul 3, 2024 · Form 483 · BSO LLC (dba Belmar Select Outsourcing), Lakewood, CO. FDA issued a Form FDA 483 to BSO LLC (dba Belmar Select Outsourcing), Lakewood, CO (503B facility) on 2024-07-03. The form lists 4 observation(s), including: procedures to prevent microbial contamination of sterile products; personnel practices. Form FDA 483 observations are inspectional and do not represent a final FDA determination of compliance. FDA record

Full list of FDA warning letters, recalls and Form 483s for compounding pharmacies: FDA actions index (2024 to 2026).

Who orders compounded Progesterone through AffinityRx

Clinic types that typically order compounded Progesterone include Women's health and menopause clinics, anti-aging clinics, functional medicine, and integrative medicine, among others.

Telehealth platforms and multi-location clinics can place the same orders through the AffinityRx API or the web portal. See also for clinics and for platforms.

Frequently asked questions about compounded Progesterone

How can a clinic pay less for compounded progesterone?

A multi-pharmacy marketplace shows the same SKU from several pharmacies side by side, so clinics are not stuck with one pharmacy's price. Clinics typically save about 10% versus their current price. Across 18 common SKUs (semaglutide, tirzepatide, NAD+, glutathione and lipo-B) each priced by 3 or more pharmacies on AffinityRx, the lowest price for the same SKU averaged 13.7% below the median pharmacy price (9.8% across the 13 GLP-1 SKUs). AffinityRx is that marketplace.

How fast does compounded progesterone ship through AffinityRx, and what does shipping cost?

Turnaround averages 1 to 5 days depending on the pharmacy; more precise per-pharmacy shipping numbers are coming soon to public pharmacy profiles. Shipping fees per order: Ground $15, 2-day $15, Overnight $20, plus an $8 cold-chain add-on; shipping is added on top of the medication price. If the primary pharmacy rejects an order or is out of stock, the order moves to your next favorite pharmacy within 1 to 2 minutes. Prescriber re-sign is the default; turning on auto re-sign removes that step.

Can clinics order progesterone through AffinityRx for office use or clinic stock?

Not available yet. Ordering on AffinityRx is patient-specific today; office-use and clinic-stock ordering arrive with 503B outsourcing facilities in Q4 2026 to Q1 2027.

Is compounded progesterone legal for my menopause clinic to order?

Yes, a state-licensed 503A pharmacy may compound progesterone on a patient-specific prescription because it is an approved-drug component with a USP-NF monograph. FDA notes compounded drugs are not FDA-approved and are not reviewed for safety or effectiveness.

Is progesterone on the FDA Category 2 list?

No, progesterone is not on FDA's Category 2 list (page updated April 2026).

Is progesterone a controlled substance?

No, progesterone is not a controlled substance, so no DEA registration is required.

What forms of compounded progesterone are available?

Commonly capsules, topical creams, vaginal preparations, troches and injectable-in-oil, depending on the pharmacy. AffinityRx shows each pharmacy's listing and price before you order.

What oils are used in compounded progesterone capsules and why does it matter for ordering?

Pharmacies commonly use oil carriers such as sesame, peanut or MCT oil. Because peanut and sesame are allergens, ask the pharmacy for the formulation sheet for each SKU.

Does AffinityRx fill progesterone orders itself?

No, AffinityRx is not a pharmacy; licensed compounding pharmacies fill orders placed through AffinityRx, which shows pharmacies side by side with prices before you order, and if the primary pharmacy rejects an order or is out of stock, the order moves to your next favorite pharmacy within 1 to 2 minutes.

Sources

Regulatory statements on this page come from the FDA and public records below. Verify current status on fda.gov before relying on it.