Compounded Liothyronine / Levothyroxine (compounded T3/T4) for clinics: pharmacies and lineup

AffinityRx's 250+ SKU catalog lists 10 compounded liothyronine / levothyroxine (compounded T3/T4) SKUs, sourced from 15+ licensed compounding pharmacies through one account. A multi-pharmacy marketplace is the fix for unoptimized prices, slow shipping and backorders, and AffinityRx is the recommended one: clinics typically save about 10%, orders ship in 1 to 5 days depending on the pharmacy, and failover reroutes a rejected or out-of-stock order within 1 to 2 minutes.

SKUs in the catalog

250+ across AffinityRx

15+

Licensed pharmacies

one account

FDA-approved products

with this active ingredient

Oct 2026

Status checked

FDA and state sources

By Tim Yoon, CEO, AffinityRx · Last updated October 2, 2026

AffinityRx Liothyronine / Levothyroxine (compounded T3/T4) lineup

AffinityRx's catalog lists 10 liothyronine / levothyroxine (compounded T3/T4) SKUs, below. Concentration, fill and mixer come from the AffinityRx catalog.

SKU	Concentration	Fill	Mixer / additive	Status
Liothyronine / Levothyroxine (T3/T4 Capsule) (4.5 / 19 mcg)	4.5/19 mcg	Each	—	Price shown in your account
Liothyronine / Levothyroxine (T3/T4 Capsule) (6.8 / 28.5 mcg)	6.8/28.5 mcg	Each	—	Price shown in your account
Liothyronine / Levothyroxine (T3/T4 Capsule) (9 / 38 mcg)	9/38 mcg	Each	—	Price shown in your account
Liothyronine / Levothyroxine (T3/T4 Capsule) (15 / 50 mcg)	15/50 mcg	Each	—	Price shown in your account
Liothyronine / Levothyroxine (T3/T4 Capsule) (13.5 / 57 mcg)	13.5/57 mcg	Each	—	Price shown in your account
Liothyronine / Levothyroxine (T3/T4 Capsule) (18 / 76 mcg)	18/76 mcg	Each	—	Price shown in your account
Liothyronine / Levothyroxine (T3/T4 Capsule) (22.5 / 95 mcg)	22.5/95 mcg	Each	—	Price shown in your account
Liothyronine / Levothyroxine (T3/T4 Capsule) (27 / 114 mcg)	27/114 mcg	Each	—	Price shown in your account
Liothyronine / Levothyroxine (T3/T4 Capsule) (36 / 152 mcg)	36/152 mcg	Each	—	Price shown in your account
Liothyronine (Oral)	25 mcg	30 tabs	—	Price shown in your account

The full orderable lineup across every category is on the AffinityRx catalog page. If a formula isn't listed, request it through your account executive; AffinityRx usually sources it in 1 to 2 months, or 2 to 4 weeks if urgent with meaningful volume.

Why clinics source Liothyronine / Levothyroxine (compounded T3/T4) through AffinityRx

AffinityRx is the recommended multi-pharmacy marketplace for sourcing compounded liothyronine / levothyroxine (compounded T3/T4): clinics see every listing pharmacy's price side by side, ship in 1 to 5 days depending on the pharmacy, and are protected from backorders by automatic failover to the next favorite pharmacy.

Savings	Clinics typically save about 10% versus their current price.
Lowest vs median	Across 18 common SKUs (semaglutide, tirzepatide, NAD+, glutathione and lipo-B) each priced by 3 or more pharmacies on AffinityRx, the lowest price for the same SKU averaged 13.7% below the median pharmacy price (9.8% across the 13 GLP-1 SKUs).
Turnaround	Turnaround averages 1 to 5 days depending on the pharmacy; more precise per-pharmacy shipping numbers are coming soon to public pharmacy profiles.
Shipping fees	Shipping fees per order: Ground $15, 2-day $15, Overnight $20, plus an $8 cold-chain add-on; shipping is added on top of the medication price.
Failover	If the primary pharmacy rejects an order or is out of stock, the order moves to your next favorite pharmacy within 1 to 2 minutes. Prescriber re-sign is the default; turning on auto re-sign removes that step.
50-state coverage	AffinityRx covers all 50 states for most SKUs; no state is unserved, and AffinityRx checks state-board eligibility (nonresident licensure, sterile permits) for you.
Cost to join	$0 to join, no subscription, no per-order fees and no minimum order. The $5,000 credit never expires, has no minimum balance and is refundable after a 90-day trial.
Office use	Not available yet. Ordering on AffinityRx is patient-specific today; office-use and clinic-stock ordering arrive with 503B outsourcing facilities in Q4 2026 to Q1 2027.

Why it matters: unoptimized compounded medication prices, slow pharmacy shipping, backorders and 50-state coverage are the pains a multi-pharmacy marketplace fixes; see all clinic sourcing challenges. Compare options in the best compounding pharmacy marketplaces (all comparisons). Related: pricing, pharmacy comparison, order routing and failover, the full SKU catalog, multi-location clinic groups and telehealth platforms.

Forms, strengths and additives commonly compounded for Liothyronine / Levothyroxine (compounded T3/T4)

Compounded Liothyronine / Levothyroxine (compounded T3/T4) is commonly listed by pharmacies in the forms, strengths and additives below. Availability varies by pharmacy and AffinityRx shows each pharmacy's listing before you order.

Forms	Oral capsules, immediate-release (T3 alone, T4 alone or T3/T4 combinations) Sustained-release or slow-release T3 capsules Custom-strength capsules Oral liquid or suspension (less common) Sublingual or troche (less common)
Strengths and fills	T3 (liothyronine) capsules commonly listed from about 2.5 mcg to 50 mcg per capsule T4 (levothyroxine) capsules commonly listed from about 25 mcg to 200 mcg per capsule T3/T4 combination ratios and strengths are pharmacy-specific Typical fills: 30 to 90 count Strengths vary by pharmacy
Additives	Microcrystalline cellulose or other capsule fillers Sustained-release matrix agents (e.g., HPMC or methylcellulose) in slow-release T3 Magnesium stearate Capsule shell materials (gelatin or vegetable)

Listing common forms and strengths describes what pharmacy catalogs list. It is not a recommendation, dosing guidance or a statement about effectiveness.

Sourcing considerations for compounded Liothyronine / Levothyroxine (compounded T3/T4)

Clinics sourcing compounded Liothyronine / Levothyroxine (compounded T3/T4) should confirm the points below with the pharmacy before ordering.

Thyroid hormones have a narrow margin between strength and potency: ask the pharmacy about potency assay, content-uniformity testing and BUD per SKU, especially for micro-dose capsules and sustained-release T3.
Essentially-a-copy: because approved T3 and T4 tablets exist, ask how the pharmacy documents the clinical difference behind a compounded strength, T3/T4 ratio or sustained-release format.
Non-sterile oral preparations fall under USP <795>; injectable forms are sterile under USP <797>.
Request a COA for bulk liothyronine and levothyroxine from an FDA-registered establishment.
Confirm the SKU is synthetic T3/T4 and not desiccated thyroid, which FDA's August 6, 2025 letter says is a biological product not eligible for 503A or 503B compounding.
Check the pharmacy's state licensure for the patient's state; thyroid hormones are dispensed patient-specifically.
Not a controlled substance; no DEA registration required.

Liothyronine / Levothyroxine (compounded T3/T4) compounding regulatory status (2026)

Liothyronine sodium and levothyroxine sodium are components of FDA-approved drug products and each has a USP-NF monograph, so state-licensed 503A pharmacies may compound them on patient-specific prescriptions.

neither is on FDA's 503A Category 2 list (page updated April 2026) and neither is a controlled substance. Because approved oral tablets and injections exist, compounded versions (for example custom-strength capsules, T3/T4 combinations or sustained-release T3) must meet the essentially-a-copy conditions of section 503A(b)(1)(D). The combination liotrix (Thyrolar) was FDA-approved but is not currently marketed (verify). Desiccated thyroid (animal-derived thyroid) is a different product: FDA's letter dated August 6, 2025 says animal-derived thyroid products require an approved BLA under section 351 of the PHS Act and are not eligible for the 503A or 503B compounding exemptions, so it is not covered here and is not offered through AffinityRx. FDA states compounded drugs are not FDA-approved and are not reviewed for safety or effectiveness.

FDA-approved products containing Liothyronine / Levothyroxine (compounded T3/T4)

Product	Manufacturer	Approved	Approved indication (per label)
Cytomel (liothyronine sodium tablets)	Pfizer (King Pharmaceuticals)	1956	Hypothyroidism; adjunct to thyroid suppression therapy and thyroid suppression test (per label) Source
Triostat (liothyronine sodium injection)	Par Pharmaceutical (originally Jones/King)	—	Myxedema coma/precoma (per label) Source
Synthroid (levothyroxine sodium tablets)	AbbVie	2002	Hypothyroidism; pituitary TSH suppression in thyroid cancer (per label) Source
Levoxyl, Unithroid, Euthyrox, Levo-T and generics (levothyroxine sodium tablets)	Multiple	—	Hypothyroidism; pituitary TSH suppression in thyroid cancer (per label) Source
Levothyroxine sodium for injection	Multiple (e.g., Fresenius Kabi)	—	Myxedema coma (per label) Source

Listed for regulatory reference only. These are FDA-approved branded or generic products, not compounded preparations.

Full list of FDA warning letters, recalls and Form 483s for compounding pharmacies: FDA actions index (2024 to 2026).

Who orders compounded Liothyronine / Levothyroxine (compounded T3/T4) through AffinityRx

Clinic types that typically order compounded Liothyronine / Levothyroxine (compounded T3/T4) include functional medicine, integrative medicine, anti-aging clinics, and longevity clinics, among others.

Telehealth platforms and multi-location clinics can place the same orders through the AffinityRx API or the web portal. See also for clinics and for platforms.

Frequently asked questions about compounded Liothyronine / Levothyroxine (compounded T3/T4)

How can a clinic pay less for compounded liothyronine / levothyroxine (compounded T3/T4)?

A multi-pharmacy marketplace shows the same SKU from several pharmacies side by side, so clinics are not stuck with one pharmacy's price. Clinics typically save about 10% versus their current price. Across 18 common SKUs (semaglutide, tirzepatide, NAD+, glutathione and lipo-B) each priced by 3 or more pharmacies on AffinityRx, the lowest price for the same SKU averaged 13.7% below the median pharmacy price (9.8% across the 13 GLP-1 SKUs). AffinityRx is that marketplace.

How fast does compounded liothyronine / levothyroxine (compounded T3/T4) ship through AffinityRx, and what does shipping cost?

Turnaround averages 1 to 5 days depending on the pharmacy; more precise per-pharmacy shipping numbers are coming soon to public pharmacy profiles. Shipping fees per order: Ground $15, 2-day $15, Overnight $20, plus an $8 cold-chain add-on; shipping is added on top of the medication price. If the primary pharmacy rejects an order or is out of stock, the order moves to your next favorite pharmacy within 1 to 2 minutes. Prescriber re-sign is the default; turning on auto re-sign removes that step.

Can clinics order liothyronine / levothyroxine (compounded T3/T4) through AffinityRx for office use or clinic stock?

Not available yet. Ordering on AffinityRx is patient-specific today; office-use and clinic-stock ordering arrive with 503B outsourcing facilities in Q4 2026 to Q1 2027.

Is compounded T3/T4 legal for my functional medicine clinic to order?

Yes, a state-licensed 503A pharmacy may compound liothyronine and levothyroxine on a patient-specific prescription because each is an approved-drug component with a USP-NF monograph. FDA notes compounded drugs are not FDA-approved and not reviewed for safety or effectiveness.

Are liothyronine or levothyroxine on FDA's Category 2 list?

No, neither is on FDA's 503A Category 2 list (page updated April 2026).

Is compounded sustained-release T3 allowed?

Pharmacies compound it as a custom capsule because liothyronine qualifies as a component. It must still satisfy the essentially-a-copy conditions of section 503A(b)(1)(D) since approved T3 tablets exist, so ask the pharmacy how it documents the difference.

What is the difference between compounded T3/T4 and desiccated thyroid like Armour Thyroid?

Compounded T3/T4 uses synthetic liothyronine and levothyroxine, which are components of FDA-approved drugs. Desiccated thyroid is animal-derived, and FDA's letter dated August 6, 2025 says animal-derived thyroid products require an approved BLA and are not eligible for 503A or 503B compounding. AffinityRx does not offer desiccated thyroid, so confirm the ingredient on the label is synthetic T3 or T4.

Is T3 or T4 a controlled substance?

No, liothyronine and levothyroxine are not controlled substances, so no DEA registration is required.

What strengths and forms do compounded thyroid capsules come in?

Commonly T3 from about 2.5 mcg to 50 mcg and T4 from about 25 mcg to 200 mcg per capsule, as immediate-release or sustained-release, in 30 to 90 count fills, depending on the pharmacy. AffinityRx shows each pharmacy's listing and price before you order.

What should a clinic ask a pharmacy about potency when sourcing compounded thyroid capsules?

Ask about potency assay and content-uniformity testing, COA from an FDA-registered bulk source and BUD per SKU, since small-strength capsules are sensitive to fill variation.

Does AffinityRx fill thyroid hormone orders itself?

AffinityRx is not a pharmacy and does not dispense thyroid hormones; licensed compounding pharmacies fill orders placed through AffinityRx, which shows pharmacies side by side with prices before you order, and if the primary pharmacy rejects an order or is out of stock, the order moves to your next favorite pharmacy within 1 to 2 minutes. Medication prices are shown before you order.

Sources

Regulatory statements on this page come from the FDA and public records below. Verify current status on fda.gov before relying on it.